Study Subject(s): Dynamics of Assembly of Multi-Protein Complexes
Course Level:PhD
Scholarship Provider: University of Copenhagen, Denmark
Scholarship can be taken at: Denmark
Eligibility:
-A master´s degree related to the subject area of the project
-Have achieved grades which are average or above
-Professional qualifications relevant to the PhD programme
-Previous publications
-Relevant work experience
-Other professional activities
-Language skills (ability to speak or willingness to learn Danish would be an advantage)
-Interpersonal skills
-Marks obtained during the first year of study on the master programme (only relevant for applicants applying for a 4-year scholarship)
Scholarship Open for International Students: No
Scholarship Description: Department of Plant Biology and Biotechnology, Faculty of Life Sciences at University of Copenhagen is offering a PhD scholarship commencing 1 October 2011 or soon thereafter.
The cell is a busy place, where supramolecular machines facilitate a diversity of biological tasks. How these machines are assembled within the crowded cellular milieu – where the likelihood of random encounters is low – and how the cellular components are able to find their way to the final destination are central questions in biological sciences. There is an increasing awareness that we have to think in terms of the interactomes as opposed to the classical one-protein-at-a-time approach. In this project we study pathway-specific supramolecular complexes using the model plant Arabidopsis and its primary defense compounds, glucosinolates, which is a powerful model system with extensive ´omics tools available. The project employs targeted and untargeted state-of-the-art protein-protein interaction methodologies to identify interacting proteins and employ advanced bioimaging technology for in vivo validation. First task will be to identify interaction partners for the enzymes in the pathway. The most promising interactions will be confirmed by pulldown or co-immunoprecipitation assays from plant tissues. Knockout mutants will be analyzed to confirm the function in vivo. We expect to gain basic knowledge about the mechanism underlying the dynamics of assembly of multi-protein complexes which is an important step towards understanding how plants defence themselves upon attack.
How to Apply: Online
Scholarship Application Deadline: 1st September 2011.
Further Scholarship Information and Application
Categories: Denmark, Scholarships, Scholarships in Europe Tags: Apply Online, compounds, Course Level, methodologies, pathway, Plant Biology, project, scholarship application deadline, subject area, validation
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